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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.
Wong, Keith S; Mabanglo, Mark F; Seraphim, Thiago V; Mollica, Antonio; Mao, Yu-Qian; Rizzolo, Kamran; Leung, Elisa; Moutaoufik, Mohamed T; Hoell, Larissa; Phanse, Sadhna; Goodreid, Jordan; Barbosa, Leandro R S; Ramos, Carlos H I; Babu, Mohan; Mennella, Vito; Batey, Robert A; Schimmer, Aaron D; Houry, Walid A.
Affiliation
  • Wong KS; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada.
  • Mabanglo MF; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada.
  • Seraphim TV; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.
  • Mollica A; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada; Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
  • Mao YQ; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada.
  • Rizzolo K; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada.
  • Leung E; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada.
  • Moutaoufik MT; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.
  • Hoell L; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.
  • Phanse S; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.
  • Goodreid J; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
  • Barbosa LRS; Institute of Physics, University of São Paulo, São Paulo, São Paulo 05508-090 Brazil.
  • Ramos CHI; Institute of Chemistry, University of Campinas UNICAMP, Campinas, São Paulo 13083-970 Brazil.
  • Babu M; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.
  • Mennella V; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada; Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
  • Batey RA; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
  • Schimmer AD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Houry WA; Department of Biochemistry, University of Toronto, 661 University Avenue, MaRS Centre, West Tower, Room 1612, Toronto, ON M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. Electronic address: walid.houry@utoronto.ca.
Cell Chem Biol ; 25(8): 1017-1030.e9, 2018 08 16.
Article in En | MEDLINE | ID: mdl-30126533
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Depsipeptides / Endopeptidase Clp / Anti-Bacterial Agents / Mitochondria Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Chem Biol Year: 2018 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Depsipeptides / Endopeptidase Clp / Anti-Bacterial Agents / Mitochondria Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Chem Biol Year: 2018 Document type: Article