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Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.
Preite, Silvia; Cannons, Jennifer L; Radtke, Andrea J; Vujkovic-Cvijin, Ivan; Gomez-Rodriguez, Julio; Volpi, Stefano; Huang, Bonnie; Cheng, Jun; Collins, Nicholas; Reilley, Julie; Handon, Robin; Dobbs, Kerry; Huq, Lutfi; Raman, Indu; Zhu, Chengsong; Li, Quan-Zhen; Li, Ming O; Pittaluga, Stefania; Uzel, Gulbu; Notarangelo, Luigi D; Belkaid, Yasmine; Germain, Ronald N; Schwartzberg, Pamela L.
Affiliation
  • Preite S; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. silvia.preite@nih.gov.
  • Cannons JL; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. silvia.preite@nih.gov.
  • Radtke AJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Vujkovic-Cvijin I; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Gomez-Rodriguez J; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Volpi S; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Huang B; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Cheng J; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Collins N; Clinica Pediatrica e Reumatologia, Centro per le Malattie Autoinfiammatorie e Immunodeficienze, Istituto Giannina Gaslini, Genoa, Italy.
  • Reilley J; Università degli Studi di Genova, Genoa, Italy.
  • Handon R; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Dobbs K; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Huq L; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Raman I; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Zhu C; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Li QZ; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Li MO; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Pittaluga S; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Uzel G; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Notarangelo LD; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Belkaid Y; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Germain RN; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Schwartzberg PL; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nat Immunol ; 19(9): 986-1000, 2018 09.
Article in En | MEDLINE | ID: mdl-30127432
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: B-Lymphocytes / T-Lymphocytes, Helper-Inducer / Germinal Center / Phosphatidylinositol 3-Kinases / Gastrointestinal Microbiome / Mutation Type of study: Health_economic_evaluation / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Immunol Year: 2018 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: B-Lymphocytes / T-Lymphocytes, Helper-Inducer / Germinal Center / Phosphatidylinositol 3-Kinases / Gastrointestinal Microbiome / Mutation Type of study: Health_economic_evaluation / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Immunol Year: 2018 Document type: Article