Dimerization misalignment in human glutamate-oxaloacetate transaminase variants is the primary factor for PLP release.

Lee, Jesi; Gokey, Trevor; Ting, Dylan; He, Zheng-Hui; Guliaev, Anton B

Lee, Jesi; Gokey, Trevor; Ting, Dylan; He, Zheng-Hui; Guliaev, Anton B.

Affiliation

Lee J; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States of America.
Gokey T; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States of America.
Ting D; Department of Biology, San Francisco State University, San Francisco, CA, United States of America.
He ZH; Department of Biology, San Francisco State University, San Francisco, CA, United States of America.
Guliaev AB; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States of America.

PLoS One ; 13(9): e0203889, 2018.

Article in En | MEDLINE | ID: mdl-30208107

Subject(s)

Aspartate Aminotransferase, Cytoplasmic/genetics; Aspartate Aminotransferase, Cytoplasmic/physiology; Pyridoxal Phosphate/metabolism; Amino Acid Substitution/genetics; Aspartate Aminotransferase, Cytoplasmic/ultrastructure; Aspartate Aminotransferases/metabolism; Binding Sites/genetics; Catalysis; Catalytic Domain; Computer Simulation; Dimerization; Glutamates/genetics; Glutamates/physiology; Humans; Models, Molecular; Molecular Dynamics Simulation; Oxaloacetates/metabolism; Principal Component Analysis; Protein Domains/genetics; Pyridoxal Phosphate/chemistry; Pyridoxal Phosphate/physiology; Vitamin B 6/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridoxal Phosphate / Aspartate Aminotransferase, Cytoplasmic Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS One Year: 2018 Document type: Article

Fulltext

XML

PubMed Links

Search on Google