Optimized Gemcitabine Therapy in Combination with E7 Peptide Immunization Elicits Tumor Cure by Preventing Ag-Specific CTL Inhibition in Animals with Large Established Tumors.

Jang, Ho-Young; Han, Baek-Sang; Kwon, Byungsuk; Sin, Jeong-Im

Jang, Ho-Young; Han, Baek-Sang; Kwon, Byungsuk; Sin, Jeong-Im.

Affiliation

Jang HY; 1 Department of Microbiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Han BS; 2 BK21 Plus Graduate Program, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Kwon B; 3 School of Biological Sciences, University of Ulsan, Ulsan, South Korea.
Sin JI; 1 Department of Microbiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.

DNA Cell Biol ; 37(10): 850-860, 2018 Oct.

Article in En | MEDLINE | ID: mdl-30227079

Subject(s)

Adenocarcinoma/therapy; Antimetabolites, Antineoplastic/pharmacology; Cancer Vaccines/administration & dosage; Combined Modality Therapy/methods; Deoxycytidine/analogs & derivatives; T-Lymphocytes, Cytotoxic/drug effects; Adenocarcinoma/genetics; Adenocarcinoma/immunology; Adenocarcinoma/pathology; Animals; Antibodies/pharmacology; Antigens, Neoplasm/administration & dosage; Antigens, Neoplasm/chemistry; Cancer Vaccines/chemistry; Cell Line, Tumor; Cytotoxicity, Immunologic/drug effects; Deoxycytidine/pharmacology; Drug Therapy/methods; Epithelial Cells/drug effects; Epithelial Cells/immunology; Epithelial Cells/pathology; Female; Humans; Immunization; Immunotherapy/methods; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oligodeoxyribonucleotides/administration & dosage; Oligodeoxyribonucleotides/chemical synthesis; Peptides/administration & dosage; Peptides/chemical synthesis; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Cytotoxic/pathology; Tumor Burden/drug effects; Tumor Necrosis Factor Receptor Superfamily, Member 9/antagonists & inhibitors; Tumor Necrosis Factor Receptor Superfamily, Member 9/genetics; Tumor Necrosis Factor Receptor Superfamily, Member 9/immunology; Gemcitabine

Key words

4-1BB; CpG-ODN; antitumor therapy; gemcitabine; peptide vaccines; tumor recurrence

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Adenocarcinoma / Combined Modality Therapy / Cancer Vaccines / Deoxycytidine / Antimetabolites, Antineoplastic Type of study: Prognostic_studies Language: En Journal: DNA Cell Biol Year: 2018 Document type: Article

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