Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.

MacDonald, Julie A; Kura, Niharika; Sussman, Carleigh; Woods, Dori C

MacDonald, Julie A; Kura, Niharika; Sussman, Carleigh; Woods, Dori C.

Affiliation

MacDonald JA; Laboratory for Aging and Infertility Research, Northeastern University, Boston, MA, 02115, USA.
Kura N; Laboratory for Aging and Infertility Research, Northeastern University, Boston, MA, 02115, USA.
Sussman C; Laboratory for Aging and Infertility Research, Northeastern University, Boston, MA, 02115, USA.
Woods DC; Laboratory for Aging and Infertility Research, Northeastern University, Boston, MA, 02115, USA. d.woods@northeastern.edu.

J Ovarian Res ; 11(1): 89, 2018 Oct 16.

Article in En | MEDLINE | ID: mdl-30326924

Subject(s)

Granulosa Cell Tumor/physiopathology; Membrane Potential, Mitochondrial; Ovarian Neoplasms/physiopathology; Survivin/antagonists & inhibitors; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology; Cell Death; Cell Line, Tumor; Cisplatin/pharmacology; Female; Humans; Oligomycins/pharmacology; Proton Ionophores/pharmacology; Survivin/physiology; TNF-Related Apoptosis-Inducing Ligand/pharmacology

Key words

BIRC5; Granulosa cell tumor; KGN; Metabolism; Mitochondria; TRAIL

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Membrane Potential, Mitochondrial / Survivin / Granulosa Cell Tumor Limits: Female / Humans Language: En Journal: J Ovarian Res Year: 2018 Document type: Article

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