Identification of a novel crizotinib-sensitive MET-ATXN7L1 gene fusion variant in lung adenocarcinoma by next generation sequencing.

Zhu, Y C; Wang, W X; Xu, C W; Zhang, Q X; Du, K Q; Chen, G; Lv, T F; Song, Y

Zhu, Y C; Wang, W X; Xu, C W; Zhang, Q X; Du, K Q; Chen, G; Lv, T F; Song, Y.

Affiliation

Zhu YC; Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang, People's Republic of China.
Wang WX; Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.
Xu CW; Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian, People's Republic of China. Electronic address: xuchunweibbb@163.com.
Zhang QX; Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
Du KQ; Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang, People's Republic of China.
Chen G; Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
Lv TF; Department of Respiratory Medicine, Jinling Hospital, Nanjing, Jiangsu, People's Republic of China.
Song Y; Department of Respiratory Medicine, Jinling Hospital, Nanjing, Jiangsu, People's Republic of China.

Ann Oncol ; 29(12): 2392-2393, 2018 12 01.

Article in En | MEDLINE | ID: mdl-30339198

Subject(s)

Adenocarcinoma of Lung/genetics; Ataxin-7/genetics; Crizotinib/pharmacology; Lung Neoplasms/genetics; Oncogene Proteins, Fusion/genetics; Proto-Oncogene Proteins c-met/genetics; Transcription Factors/genetics; Adenocarcinoma of Lung/diagnosis; Adenocarcinoma of Lung/drug therapy; Adenocarcinoma of Lung/pathology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biopsy; Crizotinib/therapeutic use; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/genetics; Female; High-Throughput Nucleotide Sequencing; Humans; Lung Neoplasms/diagnosis; Lung Neoplasms/drug therapy; Lung Neoplasms/pathology; Middle Aged; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Oncogene Proteins, Fusion / Proto-Oncogene Proteins c-met / Ataxin-7 / Adenocarcinoma of Lung / Crizotinib / Lung Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Ann Oncol Year: 2018 Document type: Article

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