IL-10 signaling prevents gluten-dependent intraepithelial CD4<sup>+</sup> cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine.

Costes, L M M; Lindenbergh-Kortleve, D J; van Berkel, L A; Veenbergen, S; Raatgeep, H R C; Simons-Oosterhuis, Y; van Haaften, D H; Karrich, J J; Escher, J C; Groeneweg, M; Clausen, B E; Cupedo, T; Samsom, J N

IL-10 signaling prevents gluten-dependent intraepithelial CD4⁺ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine.

Costes, L M M; Lindenbergh-Kortleve, D J; van Berkel, L A; Veenbergen, S; Raatgeep, H R C; Simons-Oosterhuis, Y; van Haaften, D H; Karrich, J J; Escher, J C; Groeneweg, M; Clausen, B E; Cupedo, T; Samsom, J N.

Affiliation

Costes LMM; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
Lindenbergh-Kortleve DJ; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
van Berkel LA; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
Veenbergen S; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
Raatgeep HRC; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
Simons-Oosterhuis Y; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
van Haaften DH; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands.
Karrich JJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Escher JC; Department of Pediatric Gastroenterology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
Groeneweg M; Department of Pediatrics, Maasstad Hospital, Rotterdam, 3079 DZ, The Netherlands.
Clausen BE; Institute for Molecular Medicine, University Medical Center of Johannes Gutenberg University, Mainz, 55131, Germany.
Cupedo T; Department of Hematology, Erasmus University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Samsom JN; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, 3000 CA, The Netherlands. j.samsom@erasmusmc.nl.

Mucosal Immunol ; 12(2): 479-490, 2019 03.

Article in En | MEDLINE | ID: mdl-30542112

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Celiac Disease/immunology; Interleukin-10/metabolism; Intestinal Mucosa/immunology; Intraepithelial Lymphocytes/immunology; Animals; Cell Death; Cell Differentiation; Cell Movement; Child; Cytotoxicity, Immunologic; Glutens/immunology; Granzymes/metabolism; Homeostasis; Humans; Immune Tolerance; Interleukin-10/genetics; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Signal Transduction; T-Box Domain Proteins/genetics; T-Box Domain Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Celiac Disease / Interleukin-10 / Intraepithelial Lymphocytes / Intestinal Mucosa Limits: Animals / Child / Humans Language: En Journal: Mucosal Immunol Year: 2019 Document type: Article

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