The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-ß1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers.

Collery, Philippe; Veena, Vijay; Harikrishnan, Adhikesavan; Desmaele, Didier

Collery, Philippe; Veena, Vijay; Harikrishnan, Adhikesavan; Desmaele, Didier.

Affiliation

Collery P; Society for the Coordination of Therapeutic Researches, 20220, Algajola, France. philippe.collery@gmail.com.
Veena V; Société de Coordination de Recherches Thérapeutiques, 30, avenue du port, 20220, Algajola, France. philippe.collery@gmail.com.
Harikrishnan A; Biotechnology Department, REVA University, Bangalore, 560064, India.
Desmaele D; Biotechnology Department, REVA University, Bangalore, 560064, India.

Invest New Drugs ; 37(5): 973-983, 2019 10.

Article in En | MEDLINE | ID: mdl-30632005

Subject(s)

Antineoplastic Agents/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Reactive Oxygen Species/metabolism; Rhenium/pharmacology; Selenium Compounds/pharmacology; Triple Negative Breast Neoplasms/drug therapy; Triple Negative Breast Neoplasms/metabolism; Apoptosis; Cell Proliferation; Coordination Complexes/chemistry; Coordination Complexes/pharmacology; Female; Humans; In Vitro Techniques; Insulin-Like Growth Factor I/genetics; Insulin-Like Growth Factor I/metabolism; Models, Theoretical; Rhenium/chemistry; Selenium Compounds/chemistry; Transforming Growth Factor beta1/genetics; Transforming Growth Factor beta1/metabolism; Triple Negative Breast Neoplasms/pathology; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

Key words

Cancer; IGF; ROS; Rhenium; Rhenium(I)-diselenoether; Selectivity; Selenium; TGF; VEGF

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Rhenium / Gene Expression Regulation, Neoplastic / Reactive Oxygen Species / Selenium Compounds / Triple Negative Breast Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Invest New Drugs Year: 2019 Document type: Article

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