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Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations.
Bensinger, Dennis; Stubba, Daniel; Cremer, Anjali; Kohl, Vanessa; Waßmer, Theresa; Stuckert, Johanna; Engemann, Victoria; Stegmaier, Kimberly; Schmitz, Katja; Schmidt, Boris.
Affiliation
  • Bensinger D; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Stubba D; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Cremer A; Department of Pediatric Oncology, Dana-Farber Cancer Institute , Harvard Medical School , Boston , Massachusetts 02215 , United States.
  • Kohl V; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Waßmer T; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Stuckert J; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Engemann V; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute , Harvard Medical School , Boston , Massachusetts 02215 , United States.
  • Schmitz K; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
  • Schmidt B; Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , 64287 Darmstadt , Germany.
J Med Chem ; 62(5): 2428-2446, 2019 03 14.
Article in En | MEDLINE | ID: mdl-30742435
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / High-Throughput Screening Assays / Mutation Type of study: Diagnostic_studies / Observational_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / High-Throughput Screening Assays / Mutation Type of study: Diagnostic_studies / Observational_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2019 Document type: Article