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Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Shenkar, Robert; Peiper, Amy; Pardo, Heidy; Moore, Thomas; Lightle, Rhonda; Girard, Romuald; Hobson, Nicholas; Polster, Sean P; Koskimäki, Janne; Zhang, Dongdong; Lyne, Seán B; Cao, Ying; Chaudagar, Kiranj; Saadat, Laleh; Gallione, Carol; Pytel, Peter; Liao, James K; Marchuk, Douglas; Awad, Issam A.
Affiliation
  • Shenkar R; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Peiper A; Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC (A.P., H.P., C.G., D.M.).
  • Pardo H; Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC (A.P., H.P., C.G., D.M.).
  • Moore T; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Lightle R; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Girard R; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Hobson N; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Polster SP; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Koskimäki J; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Zhang D; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Lyne SB; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Cao Y; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Chaudagar K; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Saadat L; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
  • Gallione C; Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC (A.P., H.P., C.G., D.M.).
  • Pytel P; Department of Pathology (P.P.), Biological Sciences Division, University of Chicago, IL.
  • Liao JK; Section of Cardiology (J.K.L.), Biological Sciences Division, University of Chicago, IL.
  • Marchuk D; Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC (A.P., H.P., C.G., D.M.).
  • Awad IA; From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.
Stroke ; 50(3): 738-744, 2019 03.
Article in En | MEDLINE | ID: mdl-30744543

Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Hemangioma, Cavernous, Central Nervous System / Intracranial Hemorrhages / Intracellular Signaling Peptides and Proteins / Enzyme Inhibitors / Rho-Associated Kinases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Stroke Year: 2019 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Hemangioma, Cavernous, Central Nervous System / Intracranial Hemorrhages / Intracellular Signaling Peptides and Proteins / Enzyme Inhibitors / Rho-Associated Kinases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Stroke Year: 2019 Document type: Article