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Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.
Bellavia, D; De Luca, A; Carina, V; Costa, V; Raimondi, L; Salamanna, F; Alessandro, R; Fini, M; Giavaresi, G.
Affiliation
  • Bellavia D; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address: daniele.bellavia@ior.it.
  • De Luca A; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Carina V; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Costa V; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Raimondi L; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Salamanna F; IRCCS Istituto Ortopedico Rizzoli, Laboratory of Preclinical and Surgical Studies, Bologna, Italy.
  • Alessandro R; Department of Biopathology and Medical Biotechnologies, Section of Biology and Genetics, University of Palermo, Palermo 90133, Italy; Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council, Palermo, Italy.
  • Fini M; IRCCS Istituto Ortopedico Rizzoli, Laboratory of Preclinical and Surgical Studies, Bologna, Italy.
  • Giavaresi G; IRCCS Istituto Ortopedico Rizzoli, Laboratory of Preclinical and Surgical Studies, Bologna, Italy.
Bone ; 122: 52-75, 2019 05.
Article in En | MEDLINE | ID: mdl-30772601
ABSTRACT
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Bone and Bones / Gene Expression Regulation / MicroRNAs / Epigenesis, Genetic Limits: Animals / Humans Language: En Journal: Bone Year: 2019 Document type: Article
Fulltext
Print
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Bone and Bones / Gene Expression Regulation / MicroRNAs / Epigenesis, Genetic Limits: Animals / Humans Language: En Journal: Bone Year: 2019 Document type: Article