Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.
Bone
; 122: 52-75, 2019 05.
Article
in En
| MEDLINE
| ID: mdl-30772601
ABSTRACT
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis
/
Bone and Bones
/
Gene Expression Regulation
/
MicroRNAs
/
Epigenesis, Genetic
Limits:
Animals
/
Humans
Language:
En
Journal:
Bone
Year:
2019
Document type:
Article