Boron-Catalyzed Azide Insertion of α-Aryl α-Diazoesters.
J Org Chem
; 84(7): 4478-4485, 2019 Apr 05.
Article
in En
| MEDLINE
| ID: mdl-30855950
ABSTRACT
A challenging metal-free azide insertion of α-aryl α-diazoesters in the presence of B(C6F5)3 (5 mol %) was developed for the first time. The reaction features an easy operation, wide substrate scope, and mild conditions and affords the corresponding products in moderate to high yields. More importantly, alkene and alkyne functional groups were well tolerated because no cyclopropanation or cyclopropenation was observed. Furthermore, the corresponding azide products could be converted to primary amines or 1,2,3-triazole derivatives after simple transformations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2019
Document type:
Article