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Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.
Fritz, A J; Gillis, N E; Gerrard, D L; Rodriguez, P D; Hong, D; Rose, J T; Ghule, P N; Bolf, E L; Gordon, J A; Tye, C E; Boyd, J R; Tracy, K M; Nickerson, J A; van Wijnen, A J; Imbalzano, A N; Heath, J L; Frietze, S E; Zaidi, S K; Carr, F E; Lian, J B; Stein, J L; Stein, G S.
Affiliation
  • Fritz AJ; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
  • Gillis NE; University of Vermont Cancer Center, Burlington, Vermont.
  • Gerrard DL; University of Vermont Cancer Center, Burlington, Vermont.
  • Rodriguez PD; Department of Pharmacology, Larner college of Medicine, University of Vermont, Burlington, Vermont.
  • Hong D; Cellular Molecular Biomedical Sciences Program, University of Vermont, Burlington, Vermont.
  • Rose JT; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont.
  • Ghule PN; Cellular Molecular Biomedical Sciences Program, University of Vermont, Burlington, Vermont.
  • Bolf EL; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont.
  • Gordon JA; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
  • Tye CE; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
  • Boyd JR; University of Vermont Cancer Center, Burlington, Vermont.
  • Tracy KM; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
  • Nickerson JA; University of Vermont Cancer Center, Burlington, Vermont.
  • van Wijnen AJ; University of Vermont Cancer Center, Burlington, Vermont.
  • Imbalzano AN; Department of Pharmacology, Larner college of Medicine, University of Vermont, Burlington, Vermont.
  • Heath JL; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
  • Frietze SE; University of Vermont Cancer Center, Burlington, Vermont.
  • Zaidi SK; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
  • Carr FE; University of Vermont Cancer Center, Burlington, Vermont.
  • Lian JB; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
  • Stein JL; University of Vermont Cancer Center, Burlington, Vermont.
  • Stein GS; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Genes Chromosomes Cancer ; 58(7): 484-499, 2019 07.
Article in En | MEDLINE | ID: mdl-30873710
ABSTRACT
Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Breast Neoplasms / Chromatin / Genome / Epigenesis, Genetic Type of study: Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Genes Chromosomes Cancer Year: 2019 Document type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Breast Neoplasms / Chromatin / Genome / Epigenesis, Genetic Type of study: Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Genes Chromosomes Cancer Year: 2019 Document type: Article