Pioglitazone prevents sevoflurane­induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR­Î³.

Zhang, Xiyan; Li, Ning; Lu, Lingling; Lin, Quan; Li, Liang; Dong, Ping; Yang, Bo; Li, Dongliang; Fei, Jianchun

Pioglitazone prevents sevofluraneinduced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPARÎ³.

Zhang, Xiyan; Li, Ning; Lu, Lingling; Lin, Quan; Li, Liang; Dong, Ping; Yang, Bo; Li, Dongliang; Fei, Jianchun.

Affiliation

Zhang X; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
Li N; School of Public Health, Jining Medical University, Jining, Shandong 272067, P.R. China.
Lu L; Shandong Province Jining Health School, Jining, Shandong 272067, P.R. China.
Lin Q; Shengli Oilfield Central Hospital, Dongying, Shandong 257000, P.R. China.
Li L; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
Dong P; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
Yang B; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
Li D; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.
Fei J; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.

Mol Med Rep ; 19(5): 3815-3822, 2019 May.

Article in En | MEDLINE | ID: mdl-30896803

Subject(s)

Cognitive Dysfunction/prevention & control; Hypoxia/physiopathology; Inflammation/prevention & control; Neuroimmunomodulation/drug effects; PPAR gamma/metabolism; Pioglitazone/pharmacology; Sevoflurane/toxicity; Animals; Chronic Disease; Cognitive Dysfunction/chemically induced; Cognitive Dysfunction/pathology; Disease Models, Animal; Hippocampus/drug effects; Hippocampus/metabolism; Hippocampus/pathology; Hypoglycemic Agents/pharmacology; Inflammation/chemically induced; Inflammation/pathology; Male; Microglia/drug effects; Microglia/metabolism; Microglia/pathology; Platelet Aggregation Inhibitors/toxicity; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Neuroimmunomodulation / PPAR gamma / Cognitive Dysfunction / Sevoflurane / Pioglitazone / Inflammation / Hypoxia Limits: Animals Language: En Journal: Mol Med Rep Year: 2019 Document type: Article

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