Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).

Nair, M G; Nanavati, N T; Nair, I G; Kisliuk, R L; Gaumont, Y; Hsiao, M C; Kalman, T I

Nair, M G; Nanavati, N T; Nair, I G; Kisliuk, R L; Gaumont, Y; Hsiao, M C; Kalman, T I.

J Med Chem ; 29(9): 1754-60, 1986 Sep.

Article in En | MEDLINE | ID: mdl-3091832

Subject(s)

Folic Acid Antagonists/pharmacology; Folic Acid/analogs & derivatives; Quinazolines; Animals; Chemical Phenomena; Chemistry; Folic Acid/chemical synthesis; Folic Acid/pharmacology; Folic Acid Antagonists/chemical synthesis; Lacticaseibacillus casei/drug effects; Lacticaseibacillus casei/enzymology; Lacticaseibacillus casei/growth & development; Leukemia L1210/enzymology; Streptococcus/enzymology; Structure-Activity Relationship; Thymidylate Synthase/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Folic Acid / Folic Acid Antagonists Limits: Animals Language: En Journal: J Med Chem Year: 1986 Document type: Article

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