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Decreased levels of H3K9ac and H3K27ac in the promotor region of ovarian P450 aromatase mediated low estradiol synthesis in female offspring rats induced by prenatal nicotine exposure as well as in human granulosa cells after nicotine treatment.
Fan, Guanlan; Zhang, Qi; Wan, Yang; Lv, Feng; Chen, Yunxi; Ni, Yuan; Zou, Wen; Zhang, Wei; Wang, Hui.
Affiliation
  • Fan G; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
  • Zhang Q; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China.
  • Wan Y; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China.
  • Lv F; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China.
  • Chen Y; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China.
  • Ni Y; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China.
  • Zou W; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China.
  • Zhang W; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
  • Wang H; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic ad
Food Chem Toxicol ; 128: 256-266, 2019 Jun.
Article in En | MEDLINE | ID: mdl-30959089
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovary / Aromatase / Histones / Promoter Regions, Genetic / Maternal Exposure / Estradiol / Granulosa Cells / Nicotine Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Food Chem Toxicol Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovary / Aromatase / Histones / Promoter Regions, Genetic / Maternal Exposure / Estradiol / Granulosa Cells / Nicotine Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Food Chem Toxicol Year: 2019 Document type: Article