(+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production.

Iglesias, Darío E; Bombicino, Silvina S; Boveris, Alberto; Valdez, Laura B

Iglesias, Darío E; Bombicino, Silvina S; Boveris, Alberto; Valdez, Laura B.

Affiliation

Iglesias DE; University of Buenos Aires, School of Pharmacy and Biochemistry, Physical Chemistry Division, Buenos Aires, Argentina. lbvaldez@ffyb.uba.ar.

Food Funct ; 10(5): 2528-2537, 2019 May 22.

Article in En | MEDLINE | ID: mdl-30993288

Subject(s)

Catechin/pharmacology; Electron Transport Complex I/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Heart/drug effects; Hydrogen Peroxide/metabolism; Nitric Oxide Synthase/antagonists & inhibitors; Animals; Electron Transport Complex I/chemistry; Electron Transport Complex I/metabolism; Female; Kinetics; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Mitochondria/metabolism; Myocardium/chemistry; Myocardium/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase/chemistry; Nitric Oxide Synthase/metabolism; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Nitric Oxide Synthase / Electron Transport Complex I / Enzyme Inhibitors / Heart / Hydrogen Peroxide Limits: Animals Language: En Journal: Food Funct Year: 2019 Document type: Article

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