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[Analysis on the heritability of diabetes, based on data from the Chinese adult twins].
Gan, F X; Gao, W J; Lyu, J; Yu, C Q; Wang, S F; Pang, Z C; Cong, L M; Dong, Z; Wu, F; Wang, H; Wu, X P; Jiang, G H; Wang, X J; Wang, B Y; Chang, Z; Kuja-Halkola, R; Cao, W H; Li, L M.
Affiliation
  • Gan FX; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Gao WJ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Lyu J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Yu CQ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Wang SF; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Pang ZC; Qingdao Center for Disease Control and Prevention, Qingdao 266033, China.
  • Cong LM; Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China.
  • Dong Z; Beijing Center for Disease Control and Prevention, Beijing 100013, China.
  • Wu F; Shanghai Center for Disease Control and Prevention, Shanghai 200336, China.
  • Wang H; Jiangsu Center for Disease Control and Prevention, Nanjing 210008, China.
  • Wu XP; Sichuan Center for Disease Control and Prevention, Chengdu 610041, China.
  • Jiang GH; Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
  • Wang XJ; Qinghai Center for Disease Control and Prevention, Xining 810007, China.
  • Wang BY; Harbin Medical University, Harbin 150001, China.
  • Chang Z; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Kuja-Halkola R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Cao WH; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Li LM; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 40(4): 389-393, 2019 Apr 10.
Article in Zh | MEDLINE | ID: mdl-31006196
ABSTRACT

Objective:

To analyze the heritability of diabetes among the Chinese twin adults.

Methods:

A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model.

Results:

After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively.

Conclusions:

Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Twins, Monozygotic / Asian People / Diabetes Mellitus Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: Zh Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Twins, Monozygotic / Asian People / Diabetes Mellitus Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: Zh Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2019 Document type: Article