[Analysis on the heritability of diabetes, based on data from the Chinese adult twins].
Zhonghua Liu Xing Bing Xue Za Zhi
; 40(4): 389-393, 2019 Apr 10.
Article
in Zh
| MEDLINE
| ID: mdl-31006196
ABSTRACT
Objective:
To analyze the heritability of diabetes among the Chinese twin adults.Methods:
A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model.Results:
After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively.Conclusions:
Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Twins, Monozygotic
/
Asian People
/
Diabetes Mellitus
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2019
Document type:
Article