Wearable Devices for Single-Cell Sensing and Transfection.
Trends Biotechnol
; 37(11): 1175-1188, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31072609
ABSTRACT
Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transfection
/
Biosensing Techniques
/
Monitoring, Physiologic
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Biotechnol
Year:
2019
Document type:
Article