ATP, Mg2+, Nuclear Phase Separation, and Genome Accessibility.
Trends Biochem Sci
; 44(7): 565-574, 2019 07.
Article
in En
| MEDLINE
| ID: mdl-31072688
Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These 'sieve'-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly(ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
Genome, Human
/
Cell Nucleus
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Adenosine Triphosphate
/
Magnesium
Limits:
Humans
Language:
En
Journal:
Trends Biochem Sci
Year:
2019
Document type:
Article