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The dynamic conformational landscape of the protein methyltransferase SETD8.
Chen, Shi; Wiewiora, Rafal P; Meng, Fanwang; Babault, Nicolas; Ma, Anqi; Yu, Wenyu; Qian, Kun; Hu, Hao; Zou, Hua; Wang, Junyi; Fan, Shijie; Blum, Gil; Pittella-Silva, Fabio; Beauchamp, Kyle A; Tempel, Wolfram; Jiang, Hualiang; Chen, Kaixian; Skene, Robert J; Zheng, Yujun George; Brown, Peter J; Jin, Jian; Luo, Cheng; Chodera, John D; Luo, Minkui.
Affiliation
  • Chen S; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Wiewiora RP; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Meng F; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Babault N; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Ma A; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Yu W; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Qian K; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Hu H; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Zou H; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Wang J; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Fan S; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Blum G; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Pittella-Silva F; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
  • Beauchamp KA; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Tempel W; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, United States.
  • Jiang H; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, United States.
  • Chen K; Takeda California, Science Center Drive, San Diego, United States.
  • Skene RJ; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Zheng YG; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Brown PJ; University of Chinese Academy of Sciences, Beijing, China.
  • Jin J; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Luo C; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Chodera JD; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
  • Luo M; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
Elife ; 82019 05 13.
Article in En | MEDLINE | ID: mdl-31081496
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone-Lysine N-Methyltransferase Type of study: Prognostic_studies Language: En Journal: Elife Year: 2019 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone-Lysine N-Methyltransferase Type of study: Prognostic_studies Language: En Journal: Elife Year: 2019 Document type: Article