Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma.

Zhang, Wugang; Li, Mulan; Du, Wendi; Yang, Wuliang; Li, Guofeng; Zhang, Chen; Liang, Xinli; Chen, Haifang

Zhang, Wugang; Li, Mulan; Du, Wendi; Yang, Wuliang; Li, Guofeng; Zhang, Chen; Liang, Xinli; Chen, Haifang.

Affiliation

Zhang W; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. zwgchf98@126.com.
Li M; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. 15570351171@163.com.
Du W; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. wendi_du_0216@163.com.
Yang W; Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. yangwuliang@163.com.
Li G; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. 18379973507@163.com.
Zhang C; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herb Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. 18363259880@163.com.
Liang X; Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. paln7@163.com.
Chen H; Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. chenhf88@126.com.

Molecules ; 24(11)2019 May 30.

Article in En | MEDLINE | ID: mdl-31151274

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Camptothecin/analogs & derivatives; Lung Neoplasms/drug therapy; Tissue Distribution; Animals; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Apoptosis/drug effects; Camptothecin/administration & dosage; Camptothecin/pharmacokinetics; Carcinoma, Lewis Lung; Chromatography, Liquid; Cytokines/metabolism; Disease Models, Animal; Drug Monitoring; Drugs, Chinese Herbal/administration & dosage; Drugs, Chinese Herbal/pharmacokinetics; Glycyrrhiza/chemistry; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; Male; Mice; Plant Roots/chemistry; Rhizome/chemistry; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays

Key words

10-hydroxycamptothecin; Glycyrrhizae Radix ET Rhizoma; Platycodonis Radix; anti-lung cancer efficacy; tissue distribution

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Camptothecin / Tissue Distribution / Antineoplastic Combined Chemotherapy Protocols / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Molecules Year: 2019 Document type: Article

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