Butylidenephthalide facilitates contractions via nonspecific binding to receptors in isolated guinea-pig vas deferens.

Shih, Chung-Hung; Chen, Chi-Ming; Ko, Wun-Chang

Shih, Chung-Hung; Chen, Chi-Ming; Ko, Wun-Chang.

Affiliation

Shih CH; a Department of Internal Medicine, Division of Thoracic Medicine , Taipei Medical University Hospital , Taipei , Taiwan.
Chen CM; b School of Respiratory Therapy, College of Medicine , Taipei Medical University , Taipei , Taiwan.
Ko WC; c Department of Medicinal Chemistry, School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.

Pharm Biol ; 57(1): 380-384, 2019 Dec.

Article in En | MEDLINE | ID: mdl-31155999

Subject(s)

Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Phthalic Anhydrides/pharmacology; Receptors, Adrenergic/metabolism; Vas Deferens/drug effects; Animals; Calcium Channels/metabolism; Clonidine/pharmacology; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Muscle, Smooth/metabolism; Muscle, Smooth/physiopathology; Norepinephrine/metabolism; Norepinephrine/pharmacology; Potassium Channels, Voltage-Gated/antagonists & inhibitors; Protein Binding; Vas Deferens/metabolism; Vas Deferens/physiopathology

Key words

Ca channel blockers; clonidine; noradrenaline; postjunctional K channel blockade; voltage-dependent Ca channels

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalic Anhydrides / Vas Deferens / Receptors, Adrenergic / Muscle Contraction / Muscle, Smooth Limits: Animals Language: En Journal: Pharm Biol Year: 2019 Document type: Article

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