Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation.
Nutrition
; 65: 167-172, 2019 09.
Article
in En
| MEDLINE
| ID: mdl-31170680
OBJECTIVES: First-line recommendations for the management of functional constipation include nutritional-hygienic measures. We previously showed that a natural mineral water rich in sulphates and magnesium (Hépar) is efficient in the treatment of functional constipation. The aim of this study was to consolidate those first results and determine a precise time to respond to Hépar. METHODS: This multicenter, randomized, double-blind, controlled study of the effect of Hépar on stool consistency and frequency in functional constipation included 226 outpatients. After washout, patients used 1.5 L of water daily, including 1 L of Hépar or of low-mineral water, during 14 d. In addition to a daily reporting of stool consistency by the patient, an expert investigator blindly analyzed stool consistency (Bristol stool scale) based on photographs taken by the patient. RESULTS: The primary endpoint was met. Treatment response was more frequent in the Hépar arm than in the control group at day 14 (50% versus 29%, respectively; Pâ¯=â¯0.001). Mean time to treatment response was shorter in the Hépar group (6.4 d) than in the control arm (7.3 d; Pâ¯=â¯0.013). Concomitant stool scoring was available for 60% of the patients. Scores given to 79% of the stools were similar between the patient and the expert (differences ≤1). Safety analyses showed excellent results. CONCLUSION: This study confirms the efficacy and safety of Hépar in the treatment of functional constipation and shows that it is associated with a response within 7 d. Hépar could be a safe response to the current absence of first-line medication in the treatment of functional constipation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfates
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Constipation
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Magnesium
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Mineral Waters
/
Minerals
Type of study:
Clinical_trials
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Guideline
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Nutrition
Year:
2019
Document type:
Article