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Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
Lountos, George T; Zhao, Xue Zhi; Kiselev, Evgeny; Tropea, Joseph E; Needle, Danielle; Pommier, Yves; Burke, Terrence R; Waugh, David S.
Affiliation
  • Lountos GT; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  • Zhao XZ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
  • Kiselev E; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Tropea JE; Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
  • Needle D; Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
  • Pommier Y; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Burke TR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
  • Waugh DS; Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Nucleic Acids Res ; 47(19): 10134-10150, 2019 11 04.
Article in En | MEDLINE | ID: mdl-31199869
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Phosphoric Diester Hydrolases / Enzyme Inhibitors / Ligands Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Phosphoric Diester Hydrolases / Enzyme Inhibitors / Ligands Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2019 Document type: Article