4-HNE Induces Apoptosis of Human Retinal Pigment Epithelial Cells by Modifying HSP70.

Yang, Lei-Lei; Chen, Hao; Wang, Jun; Xia, Ting; Sun, Hong; Yuan, Chun-Hui; Liu, Shi-Liang; Chen, Jian-Bin

Yang, Lei-Lei; Chen, Hao; Wang, Jun; Xia, Ting; Sun, Hong; Yuan, Chun-Hui; Liu, Shi-Liang; Chen, Jian-Bin.

Affiliation

Yang LL; Department of Ophthalmology, Wuhan Fourth Hospital (Puai Hospital), Huazhong University of Science and Technology, Wuhan, 430030, China.
Chen H; Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, 430070, China.
Wang J; Department of Laboratory Medicine, Wuhan Medical and Health Center for Women and Children, Huazhong University of Science and Technology, Wuhan, 430016, China.
Xia T; Department of Ophthalmology, Wuhan Fourth Hospital (Puai Hospital), Huazhong University of Science and Technology, Wuhan, 430030, China.
Sun H; Department of Laboratory Medicine, Wuhan Medical and Health Center for Women and Children, Huazhong University of Science and Technology, Wuhan, 430016, China.
Yuan CH; Department of Laboratory Medicine, Wuhan Medical and Health Center for Women and Children, Huazhong University of Science and Technology, Wuhan, 430016, China.
Liu SL; Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Chen JB; Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. jbchen10@163.com.

Curr Med Sci ; 39(3): 442-448, 2019 Jun.

Article in En | MEDLINE | ID: mdl-31209817

Subject(s)

Aldehydes/pharmacology; Apoptosis/drug effects; HSP70 Heat-Shock Proteins/chemistry; X-Linked Inhibitor of Apoptosis Protein/genetics; Apoptosis/genetics; Cell Line; Epithelial Cells/cytology; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Gene Expression Regulation; HSP70 Heat-Shock Proteins/genetics; HSP70 Heat-Shock Proteins/metabolism; Humans; Lipid Peroxidation; Plasmids/chemistry; Plasmids/metabolism; Protein Binding; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Retinal Pigments/metabolism; Signal Transduction; Transfection; X-Linked Inhibitor of Apoptosis Protein/antagonists & inhibitors; X-Linked Inhibitor of Apoptosis Protein/metabolism; bcl-2-Associated X Protein/genetics; bcl-2-Associated X Protein/metabolism

Key words

4-hydroxy-2-nonenal; HSP70; XIAP; apoptosis; human retinal pigment epithelial cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / HSP70 Heat-Shock Proteins / Aldehydes / X-Linked Inhibitor of Apoptosis Protein Limits: Humans Language: En Journal: Curr Med Sci Year: 2019 Document type: Article

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