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Calotetrapterins A-C, three new pyranoxanthones and their cytotoxicity from the stem bark of Calophyllum tetrapterum Miq.
Tanjung, Mulyadi; Tjahjandarie, Tjitjik Srie; Saputri, Ratih Dewi; Kurnia, Baharrani Dwi; Rachman, Muhammad Faisal; Syah, Yana Maolana.
Affiliation
  • Tanjung M; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Tjahjandarie TS; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Saputri RD; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Kurnia BD; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Rachman MF; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Syah YM; Natural Products Chemistry Research Group, Organic Chemistry Division, Bandung Institute of Technology, Bandung, Indonesia.
Nat Prod Res ; 35(3): 407-412, 2021 Feb.
Article in En | MEDLINE | ID: mdl-31305138
ABSTRACT
Three new pyranoxanthones, calotetrapterins A-C (1-3) were isolated from the stem bark of Calophyllum tetrapterum Miq along with three known xanthones, α-mangostin (4), garciniafuran (5), and pyranojacareubin (6). All structures were elucidated based on their IR, UV, HRESIMS, 1 D (1H, 13C) and 2 D (HMBC, HMQC) NMR spectral data. Compounds 1-6 were tested to P-388 cells for cytotoxic activity, compound 2 exhibited high activity with IC50 value 1.0 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calophyllum / Xanthones / Antineoplastic Agents, Phytogenic Limits: Animals Language: En Journal: Nat Prod Res Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calophyllum / Xanthones / Antineoplastic Agents, Phytogenic Limits: Animals Language: En Journal: Nat Prod Res Year: 2021 Document type: Article