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Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.
Bachmann, Nadine; von Siebenthal, Chantal; Vongrad, Valentina; Turk, Teja; Neumann, Kathrin; Beerenwinkel, Niko; Bogojeska, Jasmina; Fellay, Jaques; Roth, Volker; Kok, Yik Lim; Thorball, Christian W; Borghesi, Alessandro; Parbhoo, Sonali; Wieser, Mario; Böni, Jürg; Perreau, Matthieu; Klimkait, Thomas; Yerly, Sabine; Battegay, Manuel; Rauch, Andri; Hoffmann, Matthias; Bernasconi, Enos; Cavassini, Matthias; Kouyos, Roger D; Günthard, Huldrych F; Metzner, Karin J.
Affiliation
  • Bachmann N; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
  • von Siebenthal C; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Vongrad V; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
  • Turk T; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Neumann K; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
  • Beerenwinkel N; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Bogojeska J; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
  • Fellay J; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Roth V; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
  • Kok YL; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Thorball CW; Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland.
  • Borghesi A; SIB Swiss Institute of Bioinformatics, 4057 Basel, Switzerland.
  • Parbhoo S; IBM Research-Zurich, 8803, Rüschlikon, Switzerland.
  • Wieser M; School of Life Sciences, EPFL, 1015, Lausanne, Switzerland.
  • Böni J; Precision Medicine Unit, Lausanne University Hospital, 1011, Lausanne, Switzerland.
  • Perreau M; Department of Mathematics and Computer Science, University of Basel, 4001, Basel, Switzerland.
  • Klimkait T; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
  • Yerly S; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Battegay M; School of Life Sciences, EPFL, 1015, Lausanne, Switzerland.
  • Rauch A; School of Life Sciences, EPFL, 1015, Lausanne, Switzerland.
  • Hoffmann M; Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy.
  • Bernasconi E; Department of Mathematics and Computer Science, University of Basel, 4001, Basel, Switzerland.
  • Cavassini M; Department of Mathematics and Computer Science, University of Basel, 4001, Basel, Switzerland.
  • Kouyos RD; Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
  • Günthard HF; Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1015, Lausanne, Switzerland.
  • Metzner KJ; Division Infection Diagnostics, Department Biomedicine-Petersplatz, University of Basel, 4001, Basel, Switzerland.
Nat Commun ; 10(1): 3193, 2019 07 19.
Article in En | MEDLINE | ID: mdl-31324762
ABSTRACT
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Reservoirs / HIV Infections / HIV-1 / Anti-HIV Agents Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Nat Commun Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Reservoirs / HIV Infections / HIV-1 / Anti-HIV Agents Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Nat Commun Year: 2019 Document type: Article