Integration of hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B virus, inactivated poliomyelitis and Haemophilus influenzae type b conjugate vaccine within existing national recommendations following a birth dose of monovalent hepatitis B virus vaccine: results of a systematic review in the Asia Pacific region.
Expert Rev Vaccines
; 18(9): 921-933, 2019 09.
Article
in En
| MEDLINE
| ID: mdl-31328999
ABSTRACT
Introduction:
In Asia Pacific, most countries recommend a monovalent hepatitis B virus (HBV) vaccine dose at birth followed by primary vaccination series including three or four doses of combination vaccines against diphtheria, tetanus, and pertussis, with or without Haemophilus influenzae type b (Hib), HBV or poliomyelitis antigens. If hexavalent conjugate vaccines against diphtheria-tetanus-acellular pertussis-HBV-inactivated poliovirus-Hib (DTPa-HBV-IPV/Hib) replace the vaccines included in the primary vaccination series, co-administration of lower-valent vaccines would be avoided but infants would receive ≥4 doses of HBV-containing vaccines before the age of 2 years. Areas covered We searched for clinical trials conducted in the South-East Asia and Western Pacific Regions (World Health Organization geographic definition), investigating vaccination regimens with >3 doses of HBV-containing vaccines in infants, including a monovalent HBV vaccine birth dose and ≥1 dose of GSK's hexavalent DTPa-HBV-IPV/Hib vaccine. Expert opinion The six clinical trials included in this review showed that infants who received the monovalent HBV vaccine at birth and three or four doses of DTPa-HBV-IPV/Hib vaccine achieved protective immunogenic titers with a clinically acceptable safety profile. Our results support the integration of hexavalent DTPa-HBV-IPV/Hib vaccine within existing national recommendations in the Asia Pacific region to reduce the number of injections during infancy.Key words
Full text:
1
Collection:
01-internacional
Health context:
10_ODS3_salud_sexual_reprodutiva
/
2_ODS3
Database:
MEDLINE
Main subject:
Poliomyelitis
/
Tetanus
/
Whooping Cough
/
Hepatitis B Vaccines
/
Vaccines, Conjugate
/
Diphtheria
/
Haemophilus Infections
/
Hepatitis B
Type of study:
Guideline
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Expert Rev Vaccines
Year:
2019
Document type:
Article