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A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene.
Kemaladewi, Dwi U; Bassi, Prabhpreet S; Erwood, Steven; Al-Basha, Dhekra; Gawlik, Kinga I; Lindsay, Kyle; Hyatt, Elzbieta; Kember, Rebekah; Place, Kara M; Marks, Ryan M; Durbeej, Madeleine; Prescott, Steven A; Ivakine, Evgueni A; Cohn, Ronald D.
Affiliation
  • Kemaladewi DU; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Bassi PS; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Erwood S; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Al-Basha D; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Gawlik KI; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Lindsay K; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Hyatt E; Program in Neurosciences and Mental Health, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Kember R; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  • Place KM; Unit of Muscle Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
  • Marks RM; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Durbeej M; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Prescott SA; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Ivakine EA; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Cohn RD; Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Nature ; 572(7767): 125-130, 2019 08.
Article in En | MEDLINE | ID: mdl-31341277
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Up-Regulation / Laminin / Genes, Modifier / Muscular Dystrophies Limits: Animals Language: En Journal: Nature Year: 2019 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Up-Regulation / Laminin / Genes, Modifier / Muscular Dystrophies Limits: Animals Language: En Journal: Nature Year: 2019 Document type: Article