The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle.
Science
; 365(6455)2019 08 23.
Article
in En
| MEDLINE
| ID: mdl-31439762
ABSTRACT
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Plasmodium berghei
/
Atlases as Topic
/
Genes, Protozoan
/
Transcriptome
/
Life Cycle Stages
/
Malaria
Limits:
Animals
/
Humans
Language:
En
Journal:
Science
Year:
2019
Document type:
Article