Immunoregulation in human schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms.
Mem Inst Oswaldo Cruz
; 82 Suppl 4: 105-9, 1987.
Article
in En
| MEDLINE
| ID: mdl-3151084
ABSTRACT
Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
Search on Google
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Schistosoma mansoni
/
Schistosomiasis mansoni
/
Antibodies, Helminth
/
Antigens, Helminth
Limits:
Animals
/
Humans
Language:
En
Journal:
Mem Inst Oswaldo Cruz
Year:
1987
Document type:
Article