Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis.

Kumari, Rajni; Deshmukh, Ruhi S; Das, Sanjeev

Kumari, Rajni; Deshmukh, Ruhi S; Das, Sanjeev.

Affiliation

Kumari R; Molecular Oncology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.
Deshmukh RS; Molecular Oncology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.
Das S; Molecular Oncology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India. sdas@nii.ac.in.

Nat Commun ; 10(1): 4255, 2019 09 18.

Article in En | MEDLINE | ID: mdl-31534141

Subject(s)

ATP Citrate (pro-S)-Lyase/antagonists & inhibitors; Carcinogenesis/pathology; Caspase 10/metabolism; Epigenesis, Genetic/genetics; Neoplasms/pathology; A549 Cells; Acetyl Coenzyme A/biosynthesis; Acetylation; Animals; Carcinogenesis/genetics; Cell Line, Tumor; Cell Proliferation/genetics; Female; HCT116 Cells; HEK293 Cells; Histones/metabolism; Humans; Lipogenesis/physiology; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; p300-CBP Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP Citrate (pro-S)-Lyase / Epigenesis, Genetic / Caspase 10 / Carcinogenesis / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Nat Commun Year: 2019 Document type: Article

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