Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors.

Metze, S; Ruhl, S; Greller, G; Grimm, C; Scholz, J

Metze, S; Ruhl, S; Greller, G; Grimm, C; Scholz, J.

Affiliation

Metze S; Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079, Göttingen, Germany.
Ruhl S; Institut für Technische Chemie, Leibniz Universität Hannover, Callinstraße 5, 30559, Hannover, Germany.
Greller G; Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079, Göttingen, Germany.
Grimm C; Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079, Göttingen, Germany.
Scholz J; Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079, Göttingen, Germany.

Bioprocess Biosyst Eng ; 43(2): 193-205, 2020 Feb.

Article in En | MEDLINE | ID: mdl-31549309

Subject(s)

Batch Cell Culture Techniques; Bioreactors; Electric Capacitance; Models, Biological; Animals; Biomass; CHO Cells; Cricetulus

Key words

Capacitance; Impedance; Mammalian CHO cell culture; PAT; Process monitoring and control; Scale-up

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bioreactors / Electric Capacitance / Batch Cell Culture Techniques / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioprocess Biosyst Eng Year: 2020 Document type: Article

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