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SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.
Yoshida, Akihiro; Bu, Yiwen; Qie, Shuo; Wrangle, John; Camp, E Ramsay; Hazard, E Starr; Hardiman, Gary; de Leeuw, Renée; Knudsen, Karen E; Diehl, J Alan.
Affiliation
  • Yoshida A; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Bu Y; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Qie S; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Wrangle J; Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Camp ER; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Hazard ES; Center for Genomic Medicine Bioinformatics, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Hardiman G; Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • de Leeuw R; Center for Genomic Medicine Bioinformatics, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Knudsen KE; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Diehl JA; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Sci Adv ; 5(9): eaax6352, 2019 09.
Article in En | MEDLINE | ID: mdl-31555743
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Signal Transduction / Drug Resistance, Neoplasm / Amino Acid Transport Systems / Symporters / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 / Neoplasm Proteins Limits: Humans Language: En Journal: Sci Adv Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Signal Transduction / Drug Resistance, Neoplasm / Amino Acid Transport Systems / Symporters / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 / Neoplasm Proteins Limits: Humans Language: En Journal: Sci Adv Year: 2019 Document type: Article