The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.
DNA Repair (Amst)
; 83: 102700, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31563041
ABSTRACT
The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Cytidine Deaminase
/
Molecular Targeted Therapy
/
Neoplasms
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
DNA Repair (Amst)
Year:
2019
Document type:
Article