PBC-10: a short quality of life measure for clinical screening in primary biliary cholangitis.
Aliment Pharmacol Ther
; 50(11-12): 1223-1231, 2019 12.
Article
in En
| MEDLINE
| ID: mdl-31664722
ABSTRACT
BACKGROUND:
Current guidelines in primary biliary cholangitis ( PBC) recommend routine screening for symptoms. However, at present there are no validated practical tools suitable for screening use in practice.AIM:
To develop a short quality of life questionnaire for PBCMETHODS:
The short PBC HRQL questionnaire was derived and validated by analysing the PBC-40 questionnaires from the UK-PBC Research Cohort. Construct validity was assessed using the European Quality of Life Five Dimensions (EQ5D) questionnaire. Test-retest analysis was done by asking a subgroup of patients to complete the questionnaire twice within 2-4 weeks.RESULTS:
A total of 2219 patients completed PBC-40 questionnaire in 2013. Stepwise regression identified 10 questions that contributed to more than 95% of the PBC-40 score variance and covered the main domains of PBC. The short HRQL questionnaire, PBC-10, had good internal consistency (Cronbach's α 0.905) and item-total correlations. PBC-10 demonstrated no ceiling effects but a floor effect was noted. Further validation on 2502 patients who completed the PBC questionnaire in 2017 confirmed the psychometric properties of PBC-10. Further analysis on 186 patients showed that PBC-10 demonstrated good internal consistency (Cronbach's α = 0.936), had good reproducibility (intra-class correlation coefficient = 0.945), good correlation with the EQ5D (r = .736), and was responsive to change. A change of 4 points in the PBC-10 score would be considered clinically important.CONCLUSION:
PBC-10 is a short and valid questionnaire for assessing the HRQL in patients with PBC in clinical practice.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
/
Surveys and Questionnaires
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Liver Cirrhosis, Biliary
Type of study:
Diagnostic_studies
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Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
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Screening_studies
Aspects:
Patient_preference
Limits:
Aged
/
Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Aliment Pharmacol Ther
Year:
2019
Document type:
Article