Blocking late stages of splicing quickly limits pre-spliceosome assembly in vivo.

Mendoza-Ochoa, Gonzalo I; Barrass, J David; Maudlin, Isabella E; Beggs, Jean D

Mendoza-Ochoa, Gonzalo I; Barrass, J David; Maudlin, Isabella E; Beggs, Jean D.

Affiliation

Mendoza-Ochoa GI; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Barrass JD; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Maudlin IE; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Beggs JD; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

RNA Biol ; 16(12): 1775-1784, 2019 12.

Article in En | MEDLINE | ID: mdl-31671032

Subject(s)

Feedback, Physiological/drug effects; RNA Splicing/drug effects; RNA, Fungal/genetics; RNA, Messenger/genetics; Saccharomyces cerevisiae/drug effects; Spliceosomes/drug effects; Adenosine Triphosphatases/deficiency; Adenosine Triphosphatases/genetics; DEAD-box RNA Helicases/deficiency; DEAD-box RNA Helicases/genetics; Indoleacetic Acids/pharmacology; RNA Cleavage/drug effects; RNA Helicases/deficiency; RNA Helicases/genetics; RNA Precursors/genetics; RNA Precursors/metabolism; RNA Splicing Factors/deficiency; RNA Splicing Factors/genetics; RNA, Fungal/metabolism; RNA, Messenger/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/genetics; Spliceosomes/genetics; Spliceosomes/metabolism

Key words

Auxin; Prp22; pre-mRNA splicing; protein depletion; yeast

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / RNA, Fungal / RNA, Messenger / RNA Splicing / Spliceosomes / Feedback, Physiological Language: En Journal: RNA Biol Year: 2019 Document type: Article

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