Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.

Morse, M A; Wang, C X; Amin, S G; Hecht, S S; Chung, F L

Morse, M A; Wang, C X; Amin, S G; Hecht, S S; Chung, F L.

Affiliation

Morse MA; Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, NY 10595.

Carcinogenesis ; 9(10): 1891-5, 1988 Oct.

Article in En | MEDLINE | ID: mdl-3168166

Subject(s)

Carcinogens/toxicity; DNA/metabolism; Glucosinolates/pharmacology; Indoles/pharmacology; Methyltransferases/metabolism; Neoplasms, Experimental/pathology; Nitrosamines/toxicity; Thioglycosides/pharmacology; Animals; Diet; Glucosinolates/administration & dosage; Indoles/administration & dosage; Liver Neoplasms/chemically induced; Lung Neoplasms/chemically induced; Male; Methylation; Nitrosamines/metabolism; Nose Neoplasms/chemically induced; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms/chemically induced; Rats; Rats, Inbred F344

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Collection: 01-internacional Database: MEDLINE Main subject: Thioglycosides / DNA / Carcinogens / Glucosinolates / Indoles / Methyltransferases / Neoplasms, Experimental / Nitrosamines Limits: Animals Language: En Journal: Carcinogenesis Year: 1988 Document type: Article

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