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Acacetin Alleviates Hepatitis Following Renal Ischemia-Reperfusion in Male Balb/C Mice by Antioxidants Regulation and Inflammatory Markers Suppression.
Jalili, Cyrus; Akhshi, Nasim; Raissi, Farshid; Shiravi, Abdolhosein; Alvani, Alvand; Vaezi, Gholamhasan; Nedaei, Seyed Ershad; Ghanbari, Ali.
Affiliation
  • Jalili C; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Akhshi N; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Raissi F; Department of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Shiravi A; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
  • Alvani A; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
  • Vaezi G; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
  • Nedaei SE; Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Ghanbari A; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Invest Surg ; 34(5): 495-503, 2021 May.
Article in En | MEDLINE | ID: mdl-31686554
BACKGROUND: Ischemia-reperfusion (Isc/Rep) incidence can damage kidneys and long-distance organs such as the liver. Due to the increasing use of herbs in medicine, this study was designed to assess the effects of Acacetin (ACA) on pathophysiology of liver following renal Isc/Rep induction. Methods: 84 male Balb/C mice were divided into 12 groups including control, control + ACAs groups (0.01% DMSO or 50, 25, 10 mg/kg of ACA.) sham group (a period of 60 min laparotomy with 0.01% DMSO treatment) sham + ACAs groups (0.01% DMSO + 50, 25, 10 mg/kg of ACA) Isc/Rep treatment groups (laparotomy and bilateralrenal occlusion for 60 min with/without administration of 50, 25, 10 mg/kg ACA). All experimental groups were treated intraperitoneally daily for 4 consecutive days. The values of quantitative histology, Total Antioxidant Capacity (TAC), Nitric oxide (NO), TNFα, IL1ß, and the serum levels of hepatic enzymes were evaluated. Results: In the Isc/Rep and Isc/Rep + ACA (10 mg/kg) groups, there were a significant decrease in the level of albumin and TAC, while the other evaluated parameters were significantly increased (p < 0.05). In the Isc/Rep + ACA (25, 50 mg/kg), these parameters showed significant recovery compared to Isc/Rep + ACA (10 mg/kg) group (p < 0.05). Conclusion: Increasing the oxidant activity is the most important cause of injury in long-distance organs following Isc/Rep process. By employing the inflammatory mediators in a dose-dependent manner, the ACA reveals the recovery effects on liver failure.
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Reperfusion Injury / Hepatitis Limits: Animals Language: En Journal: J Invest Surg Year: 2021 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Reperfusion Injury / Hepatitis Limits: Animals Language: En Journal: J Invest Surg Year: 2021 Document type: Article