PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis.

Gao, Sisi; Liu, Huanting; de Crécy-Lagard, Valérie; Zhu, Wen; Richards, Nigel G J; Naismith, James H

Gao, Sisi; Liu, Huanting; de Crécy-Lagard, Valérie; Zhu, Wen; Richards, Nigel G J; Naismith, James H.

Affiliation

Gao S; Research Complex at Harwell, Didcot, OX11 0FA, UK.

Chem Commun (Camb) ; 55(96): 14502-14505, 2019 Nov 28.

Article in En | MEDLINE | ID: mdl-31730149

Subject(s)

Bacterial Proteins/metabolism; Diketopiperazines/chemistry; Formycins/biosynthesis; Pyridoxal Phosphate/chemistry; Pyridoxamine/analogs & derivatives; Transaminases/metabolism; Bacterial Proteins/antagonists & inhibitors; Bacterial Proteins/genetics; Biocatalysis; Catalytic Domain; Cycloserine/chemistry; Diketopiperazines/metabolism; Formycins/chemistry; Hydrogen-Ion Concentration; Pyridoxamine/chemistry; Pyridoxamine/metabolism; Streptomyces/chemistry; Streptomyces/metabolism; Transaminases/antagonists & inhibitors; Transaminases/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridoxal Phosphate / Pyridoxamine / Bacterial Proteins / Formycins / Diketopiperazines / Transaminases Language: En Journal: Chem Commun (Camb) Year: 2019 Document type: Article

Fulltext

XML

PubMed Links

Search on Google