Conditioning Regimens for Hematopoietic Cell Transplantation in Primary Immunodeficiency.
Curr Allergy Asthma Rep
; 19(11): 52, 2019 11 18.
Article
in En
| MEDLINE
| ID: mdl-31741098
ABSTRACT
PURPOSE OF REVIEW Hematopoietic cell transplantation (HCT) is an established curative treatment for children with primary immunodeficiencies. This article reviews the latest developments in conditioning regimens for primary immunodeficiency (PID). It focuses on data regarding transplant outcomes according to newer reduced toxicity conditioning regimens used in HCT for PID. RECENT FINDINGS:
Conventional myeloablative conditioning regimens are associated with significant acute toxicities, transplant-related mortality, and late effects such as infertility. Reduced toxicity conditioning regimens have had significant positive impacts on HCT outcome, and there are now well-established strategies in children with PID. Treosulfan has emerged as a promising preparative agent. Use of a peripheral stem cell source has been shown to be associated with better donor chimerism in patients receiving reduced toxicity conditioning. Minimal conditioning regimens using monoclonal antibodies are in clinical trials with promising results thus far. Reduced toxicity conditioning has emerged as standard of care for PID and has resulted in improved transplant survival for patients with significant comorbidities.Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
Database:
MEDLINE
Main subject:
Hematopoietic Stem Cell Transplantation
/
Transplantation Conditioning
/
Primary Immunodeficiency Diseases
Limits:
Humans
Language:
En
Journal:
Curr Allergy Asthma Rep
Year:
2019
Document type:
Article