Prolonged isolation stress accelerates the onset of Alzheimer's disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment.

Peterman, J L; White, J D; Calcagno, A; Hagen, C; Quiring, M; Paulhus, K; Gurney, T; Eimerbrink, M J; Curtis, M; Boehm, G W; Chumley, M J

Peterman, J L; White, J D; Calcagno, A; Hagen, C; Quiring, M; Paulhus, K; Gurney, T; Eimerbrink, M J; Curtis, M; Boehm, G W; Chumley, M J.

Affiliation

Peterman JL; Department of Psychology, Texas Christian University, United States.
White JD; Department of Psychology, Texas Christian University, United States.
Calcagno A; Department of Psychology, Texas Christian University, United States.
Hagen C; Department of Biology, Texas Christian University, United States.
Quiring M; Department of Biology, Texas Christian University, United States.
Paulhus K; Department of Biology, Texas Christian University, United States.
Gurney T; Department of Biology, Texas Christian University, United States.
Eimerbrink MJ; Department of Psychology, Texas Christian University, United States.
Curtis M; Department of Biology, Texas Christian University, United States.
Boehm GW; Department of Psychology, Texas Christian University, United States.
Chumley MJ; Department of Biology, Texas Christian University, United States. Electronic address: m.chumley@tcu.edu.

Behav Brain Res ; 379: 112366, 2020 02 03.

Article in En | MEDLINE | ID: mdl-31743728

Subject(s)

Alzheimer Disease; Amyloid Precursor Protein Secretases/metabolism; Aspartic Acid Endopeptidases/metabolism; Cognitive Dysfunction; Hippocampus/metabolism; Physical Conditioning, Animal/physiology; Plaque, Amyloid/metabolism; Social Isolation; Stress, Psychological; Alzheimer Disease/etiology; Alzheimer Disease/metabolism; Alzheimer Disease/prevention & control; Amyloid beta-Peptides/metabolism; Animals; Cognitive Dysfunction/etiology; Cognitive Dysfunction/metabolism; Cognitive Dysfunction/prevention & control; Disease Models, Animal; Environment; Housing, Animal; Male; Mice; Mice, Transgenic; Running/physiology; Stress, Psychological/complications; Stress, Psychological/metabolism; Stress, Psychological/prevention & control

Key words

5xFAD; Amyloid beta; Exercise; Memory; Social isolation; Stress

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 Database: MEDLINE Main subject: Physical Conditioning, Animal / Social Isolation / Stress, Psychological / Aspartic Acid Endopeptidases / Plaque, Amyloid / Amyloid Precursor Protein Secretases / Alzheimer Disease / Cognitive Dysfunction / Hippocampus Type of study: Etiology_studies / Prognostic_studies Aspects: Determinantes_sociais_saude Limits: Animals Language: En Journal: Behav Brain Res Year: 2020 Document type: Article

Fulltext

XML

PubMed Links

Search on Google