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Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia.
Pearson, Jennifer M; Tan, Su-Fern; Sharma, Arati; Annageldiyev, Charyguly; Fox, Todd E; Abad, Jose Luis; Fabrias, Gemma; Desai, Dhimant; Amin, Shantu; Wang, Hong-Gang; Cabot, Myles C; Claxton, David F; Kester, Mark; Feith, David J; Loughran, Thomas P.
Affiliation
  • Pearson JM; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia.
  • Tan SF; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, Virginia.
  • Sharma A; Penn State Cancer Institute, Hershey, Pennsylvania.
  • Annageldiyev C; Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania.
  • Fox TE; Penn State Cancer Institute, Hershey, Pennsylvania.
  • Abad JL; Department of Pharmacology, University of Virginia, Charlottesville, Virginia.
  • Fabrias G; Department of Biological Chemistry, Networking Biomedical Research Centre on Liver and Digestive Diseases (CIBER-EHD), Institute for Advanced Chemistry of Catalonia, Spanish National Research Council (IQAC-CSIC), Barcelona, Spain.
  • Desai D; Department of Biological Chemistry, Networking Biomedical Research Centre on Liver and Digestive Diseases (CIBER-EHD), Institute for Advanced Chemistry of Catalonia, Spanish National Research Council (IQAC-CSIC), Barcelona, Spain.
  • Amin S; Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania.
  • Wang HG; Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania.
  • Cabot MC; Penn State Cancer Institute, Hershey, Pennsylvania.
  • Claxton DF; Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania.
  • Kester M; Department of Biochemistry and Molecular Biology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
  • Feith DJ; Penn State Cancer Institute, Hershey, Pennsylvania.
  • Loughran TP; Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania.
Mol Cancer Res ; 18(3): 352-363, 2020 03.
Article in En | MEDLINE | ID: mdl-31744877
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Sphingolipids / Leukemia, Myeloid, Acute / Ceramides / Myeloid Cell Leukemia Sequence 1 Protein Type of study: Prognostic_studies Limits: Aged / Animals / Female / Humans Language: En Journal: Mol Cancer Res Year: 2020 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Sphingolipids / Leukemia, Myeloid, Acute / Ceramides / Myeloid Cell Leukemia Sequence 1 Protein Type of study: Prognostic_studies Limits: Aged / Animals / Female / Humans Language: En Journal: Mol Cancer Res Year: 2020 Document type: Article