Fluoroquinolone antibiotics show genotoxic effect through DNA-binding and oxidative damage.

Bhattacharya, Prabuddha; Mukherjee, Srasta; Mandal, Santi M

Bhattacharya, Prabuddha; Mukherjee, Srasta; Mandal, Santi M.

Affiliation

Bhattacharya P; Department of Chemistry, Adamas University, Kolkata, 700126, India. Electronic address: prabuddha.bhattacharya@adamasuniversity.ac.in.
Mukherjee S; Department of Chemistry, Adamas University, Kolkata, 700126, India.
Mandal SM; Central Research Facility, Indian Institute of Technology, Kharagpur, 721302, WB, India. Electronic address: mandalsm@gmail.com.

Spectrochim Acta A Mol Biomol Spectrosc ; 227: 117634, 2020 Feb 15.

Article in En | MEDLINE | ID: mdl-31756649

Subject(s)

Anti-Bacterial Agents/pharmacology; DNA Damage; DNA/metabolism; Fluoroquinolones/pharmacology; Mutagens/toxicity; Oxidative Stress; Anti-Bacterial Agents/chemistry; Ethidium/metabolism; Fluorescence; Fluoroquinolones/chemistry; HEK293 Cells; Humans; Kinetics; Molecular Docking Simulation; Oxidative Stress/drug effects; Spectrophotometry, Ultraviolet

Key words

Docking; Ethidium bromide; Fluorescence; Fluoroquinolones; Genotoxicity; MTT assay; ROS; UVVis absorption; Western immunoblotting assay

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / DNA / Oxidative Stress / Fluoroquinolones / Anti-Bacterial Agents / Mutagens Limits: Humans Language: En Journal: Spectrochim Acta A Mol Biomol Spectrosc Year: 2020 Document type: Article

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