Effects of thalidomide on Th17, Treg cells and TGF-ß1/Smad3 pathway in a mouse model of systemic sclerosis.

Lu, Yi; Zhao, Cheng; Lei, Ling; Tao, Zhiqing; Zheng, Leting; Wen, Jing; Li, Xi

Lu, Yi; Zhao, Cheng; Lei, Ling; Tao, Zhiqing; Zheng, Leting; Wen, Jing; Li, Xi.

Affiliation

Lu Y; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Zhao C; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Lei L; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Tao Z; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Zheng L; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Wen J; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Li X; Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.

Int J Rheum Dis ; 23(3): 406-419, 2020 Mar.

Article in En | MEDLINE | ID: mdl-31840939

Subject(s)

Immunosuppressive Agents/pharmacology; Lung/drug effects; Pulmonary Fibrosis/prevention & control; Scleroderma, Systemic/drug therapy; Skin/drug effects; Smad3 Protein/metabolism; T-Lymphocytes, Regulatory/drug effects; Th17 Cells/drug effects; Thalidomide/pharmacology; Transforming Growth Factor beta1/metabolism; Animals; Cytokines/metabolism; Disease Models, Animal; Female; Fibrosis; Hydroxyproline/metabolism; Lung/immunology; Lung/metabolism; Lung/pathology; Mice, Inbred BALB C; Phosphorylation; Pulmonary Fibrosis/immunology; Pulmonary Fibrosis/metabolism; Pulmonary Fibrosis/pathology; Scleroderma, Systemic/immunology; Scleroderma, Systemic/metabolism; Scleroderma, Systemic/pathology; Signal Transduction; Skin/immunology; Skin/metabolism; Skin/pathology; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism; Th17 Cells/immunology; Th17 Cells/metabolism

Key words

SSc; TGF-ß1; Th17; Thal; Treg

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Scleroderma, Systemic / Skin / Thalidomide / T-Lymphocytes, Regulatory / Smad3 Protein / Transforming Growth Factor beta1 / Th17 Cells / Immunosuppressive Agents / Lung Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Rheum Dis Year: 2020 Document type: Article

Fulltext

XML

PubMed Links

Search on Google