Next-Generation Sequencing Identifies <i>BRCA1</i> and/or <i>BRCA2</i> Mutations in Women at High Hereditary Risk for Breast Cancer with Shorter Telomere Length.

Peker Eyüboglu, Irem; Yenmis, Güven; Bingöl, Elif Naz; Yüksel, Sirin; Tokat, Fatma; Özbek, Pemra; Güllü Amuran, Gökçe; Yakicier, Cengiz; Akkiprik, Mustafa

Next-Generation Sequencing Identifies BRCA1 and/or BRCA2 Mutations in Women at High Hereditary Risk for Breast Cancer with Shorter Telomere Length.

Peker Eyüboglu, Irem; Yenmis, Güven; Bingöl, Elif Naz; Yüksel, Sirin; Tokat, Fatma; Özbek, Pemra; Güllü Amuran, Gökçe; Yakicier, Cengiz; Akkiprik, Mustafa.

Affiliation

Peker Eyüboglu I; Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey.
Yenmis G; Biruni University Medical School, Department of Medical Biology and Genetics, Istanbul, Turkey.
Bingöl EN; Department of Bioengineering, Institute of Pure and Applied Sciences, Marmara University, Kadikoy, Istanbul, Turkey.
Yüksel S; Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Tokat F; Department of Pathology, Subdivision of Cytopathology, Acibadem University, Istanbul, Turkey.
Özbek P; Acibadem Research Institute of Senology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Güllü Amuran G; Department of Bioengineering, Faculty of Engineering, Marmara University, Kadikoy, Istanbul, Turkey.
Yakicier C; Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey.
Akkiprik M; Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

OMICS ; 24(1): 5-15, 2020 01.

Article in En | MEDLINE | ID: mdl-31851867

Subject(s)

BRCA1 Protein/genetics; BRCA2 Protein/genetics; Breast Neoplasms/genetics; Genetic Predisposition to Disease; Mutation; Telomere Shortening; Alleles; BRCA1 Protein/chemistry; BRCA2 Protein/chemistry; Female; Genotype; High-Throughput Nucleotide Sequencing; Humans; Models, Molecular; Protein Conformation; Real-Time Polymerase Chain Reaction; Risk Assessment; Risk Factors; Structure-Activity Relationship

Key words

BRCA1; BRCA2; breast cancer; family history; next-generation sequencing; telomere length

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / BRCA1 Protein / Genetic Predisposition to Disease / BRCA2 Protein / Telomere Shortening / Mutation Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: OMICS Year: 2020 Document type: Article

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