Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response.

Ramirez, Manuel U; Hernandez, Salvador R; Soto-Pantoja, David R; Cook, Katherine L

Ramirez, Manuel U; Hernandez, Salvador R; Soto-Pantoja, David R; Cook, Katherine L.

Affiliation

Ramirez MU; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Hernandez SR; Digital Illustrator, Winston Salem, NC 27103, USA.
Soto-Pantoja DR; Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Cook KL; Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA.

Int J Mol Sci ; 21(1)2019 Dec 25.

Article in En | MEDLINE | ID: mdl-31881743

Subject(s)

Endoplasmic Reticulum Stress; Neoplasms/pathology; Tumor Microenvironment; Unfolded Protein Response; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases/metabolism; Heat-Shock Proteins/metabolism; Humans; Neoplasms/immunology; Neoplasms/metabolism; Protein Serine-Threonine Kinases/metabolism; Signal Transduction; T-Lymphocytes/cytology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; eIF-2 Kinase/metabolism

Key words

Activating transcription factor 6 (ATF6); Glucose-regulated protein 78 (GRP78); Inositol-requiring enzyme 1 (IRE1); PKR-like endoplasmic reticulum kinase (PERK); T cell; immune cells; macrophage; tumor microenvironment; unfolded protein response

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Unfolded Protein Response / Tumor Microenvironment / Endoplasmic Reticulum Stress / Neoplasms Limits: Humans Language: En Journal: Int J Mol Sci Year: 2019 Document type: Article

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