Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.

Azumaya, Caleigh M; Linton, Emily A; Risener, Caitlin J; Nakagawa, Terunaga; Karakas, Erkan

Azumaya, Caleigh M; Linton, Emily A; Risener, Caitlin J; Nakagawa, Terunaga; Karakas, Erkan.

Affiliation

Azumaya CM; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Linton EA; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Risener CJ; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
Nakagawa T; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232; Center for Structural Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232; Vanderbilt Brain Institute, Vanderbilt University, School of Medicine, Nashv
Karakas E; Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232; Center for Structural Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232. Electronic address: erkan.karakas@vanderbilt.edu.

J Biol Chem ; 295(6): 1743-1753, 2020 02 07.

Article in En | MEDLINE | ID: mdl-31915246

Subject(s)

Inositol 1,4,5-Trisphosphate Receptors/metabolism; Inositol 1,4,5-Trisphosphate/metabolism; Peptides/metabolism; Binding Sites; Calcium Signaling; Cryoelectron Microscopy; Humans; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors; Inositol 1,4,5-Trisphosphate Receptors/chemistry; Inositol 1,4,5-Trisphosphate Receptors/ultrastructure; Models, Molecular; Protein Conformation

Key words

calcium channel; calcium intracellular release; cell signaling; cryo-electron microscopy; inositol trisphosphate receptor (InsP3R); ion channel; isothermal titration calorimetry (ITC); self-binding peptide; structural biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Inositol 1,4,5-Trisphosphate / Inositol 1,4,5-Trisphosphate Receptors Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2020 Document type: Article

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