Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).

Duan, Tian-Li; Jiao, Han; He, Guang-Jun; Yan, Yong-Bin

Duan, Tian-Li; Jiao, Han; He, Guang-Jun; Yan, Yong-Bin.

Affiliation

Duan TL; State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Jiao H; State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
He GJ; State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yan YB; State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Cells ; 9(1)2020 01 09.

Article in En | MEDLINE | ID: mdl-31936572

Subject(s)

Endoplasmic Reticulum/metabolism; Exoribonucleases/metabolism; Protein Biosynthesis; RNA Stability; Cell Membrane/metabolism; DNA Damage; Exoribonucleases/chemistry; HEK293 Cells; HeLa Cells; Humans; Models, Biological; Phosphorylation; Phosphoserine/metabolism; Protein Binding; Protein Domains; Proto-Oncogene Proteins c-mdm2/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism

Key words

DNA damage response; ER-anchored ribonuclease; ER-associated mRNAs; deadenylation; mRNA decay; poly(A) length profile; poly(A)-specific ribonuclease; translation efficiency

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / RNA Stability / Endoplasmic Reticulum / Exoribonucleases Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Cells Year: 2020 Document type: Article

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